Depoimentos De Quem Já Tomou Bupropiona – Paroxetine hydrochloride is an antidepressant used in urology for the treatment of premature ejaculation with excellent results and fewer side effects.
It is an antidepressant used in cases of depression, phobias, obsessive compulsive disorder, panic disorder and is also widely used in urology to treat cases of premature ejaculation.
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There are all kinds of conditions, from patients who adapt perfectly to low doses to patients who need to increase the dose to achieve the desired effect. There are also patients who do not adapt, do not improve their condition and need a change in medication. I usually switch to clomipramine.
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The main side effects can be nausea, dry mouth, insomnia, excessive sweating, tremors, dizziness, drowsiness, weakness, constipation, diarrhea, vomiting and decreased appetite.
A minimal number of patients use this dose, but it can be used in patients who do not improve at doses of 20 mg or 30 mg.
This is one of the main side effects of the drug, and it is also an indication to change the drug in some cases.
This effect is highly variable and may cause drowsiness in some patients and insomnia in others.
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It is possible to feel this good effect in a large majority of the population. In some, it is necessary to adjust the dose, and in others it is necessary to change the active ingredient, such as clomipramine.
It can cause loss of libido in some patients due to the effects of antidepressants, leading to erectile dysfunction.
In most patients around 7 to 10 days, these symptoms have completely disappeared.
It will depend a lot on the number of intercourses the patient has during the week, and it can be used only during the day or taken daily.
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Many patients come back very happy with the results of the drug, both in depression and premature ejaculation.
In patients who use it for premature ejaculation, we recommend using 2 capsules 4 hours before sex. The effect usually lasts 24 hours or more.
Some patients may experience dry mouth, vomiting, nausea, insomnia, but these symptoms usually disappear after 7 days of use.
Patients are very satisfied with this union, which will give hardness of the penis, related to the durability of the erection.
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In fact, it can worsen erectile dysfunction in patients who are already prone to it. It is always ideal to talk to the patient, so as not to take the wrong medicine and make the situation worse.
Significant weight gain may occur, but loss of libido may occur in patients who have already deteriorated their previous sexual status.
A very common association among women who experience loss of libido with paroxetine use, patients taking bupropion have been shown to increase their libido.
In the medication manual, there is a report of premature ejaculation with the start of use. But in practice, what we see is delayed premature ejaculation.
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Dapoxetine should only be used on the day of intercourse. It would be an ideal world if it were cheaper. But because of the cost, we opted for paroxetine.
Yes, this is a drug that can only be sold with a prescription issued in consultation with your urologist
This antidepressant aims to reduce anxiety, thereby improving premature ejaculation
Did you like the article? Still in doubt? Please visit my blogs where I have other related articles. In addition, I have a channel on YouTube where I talk about various problems of urology. I imagine you came here to learn more about some of the drugs that can help you lose weight, right?
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Well, did you know that the same medicine that helps you lose weight is also used to treat depression, improve energy levels, mood, and enjoyment of daily activities? Not only that, it is also a medicine that is used to stop smoking! But there is a catch…
If you read the manual of the drug, you will see that there is no mention of its use in the treatment of obesity and weight loss. That’s because it’s an off-label use, and today, here, I’ll explain why.
Bupropion, sold under the brand names Wellbutrin, Bup, Zyban, Zetron, Seth, is an antidepressant used primarily to treat major depressive disorder and to help quit smoking.
It is an effective antidepressant drug on its own, but is popularly used as an adjunctive treatment in cases of incomplete response to conventional drugs for the treatment of depression, such as SSRIs, selective serotonin reuptake inhibitors, which act on different neurotransmitters.
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It is a drug with several properties that distinguish it from other antidepressants: it can reduce sexual dysfunction and improve libido, it is not associated with weight gain, and it is more effective in improving symptoms such as fatigue and hypersomnia.
It is a drug that acts as a dopamine and norepinephrine reuptake inhibitor, meaning it will increase the availability and performance of these neurotransmitters. Unlike traditional antidepressants, it does not act on serotonin and can therefore worsen anxiety conditions.
Each drug has a different action and should only be prescribed by your doctor after a detailed medical history. In my office, the initial consultation lasts approximately 1 hour, where I identify all the patient’s complaints and disorders related to the chief complaint; only then can I recommend the best treatment. You can learn more about my question here.
Well, that’s not the topic of today’s post. And where does bupropion fit into weight loss?
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Several clinical trials have found that bupropion also has a weight-loss effect, an anorexic (appetite-reducing) action linked to excitatory proopiomelanocortin (POMC)-producing neurons in the arcuate nucleus of the hypothalamus.
This POMC is broken down into alpha-MSH, a peptide that acts on MC4 receptors, reducing food intake and increasing energy expenditure. But here we have to be careful: clinical trials only achieved normal weight loss, not enough for the FDA criteria for approval as a monotherapy for obesity.
The problem is that the excited neurons also release beta-endorphins, which act by performing a feedback mechanism, that is, they perceive the anorexigenic effect of alpha-MSH, and regulate this mechanism so that it returns to normal, decreasing POMC and the body itself. . Alpha-MSH! But what happens if we block this feedback mechanism?
Another drug comes, naltrexone. Bupropion alone is not approved for the treatment of obesity, but in the United States it is approved by the FDA while Naltrexone – a drug known there as Contrav, and not available here in Brazil, but we can manipulate the combination.
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Naltrexone is an opioid receptor antagonist used in the treatment of alcohol and opioid addiction. Remember beta-endorphins? This drug will block its action, preventing the reaction and maintaining the anorexic action of alpha-MSH!
Now yes, this combination leads to significant weight loss and can be used in the treatment of obesity.
Vía Verde et al. In one study, after 56 weeks of study, with 16 mg naltrexone + 360 mg bupropion, weight loss was -4.9 kg. Loss was -6.1 kg using 32 mg naltrexone + 360 bupropion; And the placebo group lost 1.4 kg.
Apovian et al. In a study by , weight loss using 32 mg naltrexone + 360 mg bupropion daily was -7.6 kg after 28 weeks and -7.9 kg after 56 weeks. Little difference after half the treatment, but the placebo group managed to regain some of the weight they had lost!
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Bupropion is contraindicated in people who have had a seizure episode in their lifetime, as its use lowers the seizure threshold and may increase the likelihood of a new episode.
Nausea, headache, constipation, dizziness, vomiting and dry mouth. These are the most common side effects of using the bupropion and naltrexone combination. After the most common nausea, trigger, headache. The effects improve over time.
Contrave, sold in the United States as a combination of 90 mg of bupropion and 8 mg of naltrexone, recommends a gradual increase in dosage to reduce side effects and improve treatment adherence. The goal is to achieve a single dose of 180 mg bupropion + 16 mg naltrexone, taken twice daily.
In my clinical practice, I see a great response from patients with doses as low as 75 + 7.5. Gradually increasing up to two doses a day. It is a dosage with fewer side effects and makes it easier for the patient to follow the meal plan. But then what makes the difference is the improvement of other lifestyle habits, the practice of physical activity and food, in addition to the adjustment of all the necessary hormones: in obese patients, the lack of hormones such as testosterone, cortisol, thyroid hormone , etc. vitamin D, GH, among others, is very common. And they should adjust for better results.
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If you liked this post, please send it to a friend who might be interested in this topic, and click below to schedule an appointment. New drugs are discovered every day, each with a more sophisticated mechanism of action and more precise effects. In this sense, the medicine hydrochloride