Aöf Sınav Giriş Belgesi 2019 Bahar

Aöf Sınav GiriÅŸ Belgesi 2019 Bahar – 2 BİLGE INTERNATIONAL SCIENCE AND TECHNOLOGY RESEARCH JOURNAL Volume: 3 Issue: ISSN: X e-issn: Owner: Dr. Hamza KANDEMİR Editor-in-Chief: Prof. Dr. Co-editor Kürşad ÖZKAN: Prof. Prof. Dr. Mustafa KARABOYACI Technical Editor: Res. Asst. Abdullah BERAM Instructor Serkan ÖZDEMİR Technical Assistant: Instructor Doğan AKDEMİR Office Work: Tunahan ÇINAR Cover Designer: Instructor Serkan ÖZDEMİR Press: Kutbilge Association of Academicians Distribution, Sales, Publisher; Certificate number: , Isparta, TURKEY Contact: Kutbilge Association of Academicians, 32040, Isparta, TURKEY Web Dergipark.gov.tr/bilgesci : Advisory Editorial Board: Ahmet AKSOY, Prof. Dr. Akdeniz University, Turkey Amer KANAN, Prof. Dr. Al-Quds University, Palestine Cünyt ÇIRAK, Prof. Dr. Ondokuz Mayıs University, Turkey Ander MAKİNECİ, Prof. Dr. Istanbul University, Turkey Gulcan ÖZKAN, Prof. Dr. Süleyman Demiral University, Turkey İbrahim ÖZDEMİR, Prof. Dr. Isparta University of Applied Sciences, Turkey Kari HELİÖVAARA, Prof. Dr. University of Helsinki, Finland Kirli MÜRTEZAOĞLU, Prof. Dr. Gezi University, Turkey Mehmet Kili, Prof. Dr. Suleyman Demiral University, Turkey Mehmet Kit, Prof. Dr. Suleyman Demiral University, Turkey Mohammad Lahbib BEN JAMAA, Prof. Dr. INRGREF, Tunisia Rene van den Houben, Prof. Dr. University of Vet. Med. Vienna, Austria Semra KILIÇ, Prof. Dr. Suleiman Demiral University, Turkey Steve Woodward, Prof. Dr. University of Aberdeen, UK Editorial Board: Ali Cesur ONMAZ, Prof. Associate Dr. Erciyes University, Turkey Asko Tapio LEHTİJÄRVI, Associate Dr. Bursa Technical University, Turkey Halil GÖKÇE, Prof. Associate Dr. Giresun University, Turkey Kubilay AKÇAÖZOĞLU, Associate Dr. Niğde Ömer Halisdemir University, Turkey Şule Sultan UĞUR, Prof. Associate Dr. Suleiman Demiral University, Turkey Ahmet MERT, Associate Prof. Dr. Isparta University of Applied Sciences, Turkey Ayşe KOCABIYIK, Asst. Associate Dr. Suleiman Demiral University, Turkey Aziz ŞENCAN, Associate Prof. Dr. Süleyman Demirel University, Turkey Fecir DURAN, Asst. Associate Dr. Gazi University, Turkey Kubilay TAŞDLEN, Associate Prof. Dr. Suleyman Demiral University, Turkey Nuri ÖZTÜRK, Asst. Associate Professor Dr. Giresun University, Turkey Ramadan SENOL, Associate Prof. Dr. Isparta University of Applied Sciences, Turkey

3 BILGE INTERNATIONAL JOURNAL OF SCIENCE AND TECHNOLOGY Research Volume: 3 Issue: ISSN: X e-issn : Franchise: Dr. Hamza KANDEMİR Editor: Prof. Dr. Kürşad ÖZKAN Associate Author: Dr. Teaching Member Mustafa KARABOYACI Technical Editor: Res. See. Lecturer Abdullah BERAM See. Serkan ÖZDEMİR Technical Assistant: Lect. See. Doğan AKDEMİR Office Works: Tunahan ÇINAR Cover Design: Lect.İRİ Printing ÖZDEMİR Kutbilge Academician Association, Distribution, Sales, Publisher No: , Isparta, Turkey Contact: Kutbilge Academician Association, 32040, Isparta, TURKEY Web Dergipark.gov .tr/bilgesci : Advisory Board: Ahmet AKSOY, Prof. Dr. Akdeniz University, Turkey Amer KANAN, Prof. Al-Quds University, Palestine Cünyt ÇIRAK, Prof Dr. Ondokuz Mayıs University, Turkey Ander MAKİNECİ, Prof. Istanbul University Dr., Turkey Gülcan ÖZKAN, Prof. Dr. Suleyman Demiral University, Turkey İbrahim ÖZDEMİR, Prof. Dr. Isparta App. University of Science, Turkey Kari HELIÖVAARA, Prof. Dr. University of Helsinki, Finland Kırali MÜRTEZAOĞLU, Prof. Dr. Gezi University, Turkey Mehmet Kili, Prof. Dr. Süleyman Demirel University, Turkey Mehmet KİTİŞ, Prof. Dr. Süleyman Demirel University, Turkey Mohamed Lahbib BEN JAMAA, Prof. Dr. INRGREF, Tunisia Conference Author: Ali Cesur ONMAZ, Prof. Dr. University Erciyes, Turkey Asko Tapio LEHTİJÄRVI, Associate Dr. Bursa Technical University, Turkey Halil GÖKÇE, Prof. Dr. University Giresun, Turkey Kubilay AKÇAÖZOĞLU, Associate Dr. Niğde Ömer Halisdemir University, Turkey Şule Sultan UĞUR, Prof. Dr. University Süleyman Demirel, Turkey Ahmet MERT, Associate Dr. Isparta application. University of Science, Turkey Ayşe KOCABIYIK, Dr. Associate Professor at Süleyman Demirel University, Turkey Aziz ŞENCAN, Dr. Associate Professor at Süleyman Demirel University, Turkey Fecir DURAN, Dr. Associate Professor at Gezi University, Turkey Kubilay TAŞDELEN, Dr. Expert guide in Isparta Appl. University of Science, Turkey Nuri ÖZTÜRK, Dr. Lecturer at Giresun University, Turkey Rene van den HOVEN, Prof. Vienna Veterinary University, Austria Semra KILIÇ, Prof Dr. Suleiman Demiral University, Turkey Steve Woodward, Prof. Dr. University of Aberdeen, UK Ramazan SENOL, Dr. Faculty Member of the University of Appl Science. Isparta, Turkey

Aöf Sınav Giriş Belgesi 2019 Bahar

Aöf Sınav Giriş Belgesi 2019 Bahar

4 BİLGE JOURNAL OF INTERNATIONAL SCIENCE AND TECHNOLOGY RESEARCH ISSN: X e-issn: Peer-reviewed journal, published annually by the Kutbilge Academic Association. It is a peer-reviewed journal published twice a year. It is published by the Kotbilga Academy Association. Year/Year: 2019, Volume/Volume: 3, Issue/Issue: 1 Journal indexed by Researchbib, AcademicKey, International Institute for Organized Research (I2OR), Cosmos Index, Google Scholar, Journal Factor, Index Copernicus, JIFACTOR, Science Index Directory , Index, Create Root Index, Eurasian Science Journal Index (ESJI), Guide to Research Journal Indexing (DRJI), ROAD, Researchx and BASE. Our journals Researchbib, AcademicKey, International Institute for Organized Research (I2OR), Cosmos Index, Google Scholar, Journal Factor, Copernicus Index, JIFACTOR, Science Library Index, Sindex, Root Indexing, Eurasian Scientific Journal Index (ESJI), Research Journal Index Directory ( DRJI) scanned in ROAD, Researchx and BASE.

Elif Basar. Dr. Başar Akman

5 Bilge International Journal of Science and Technology Research Year: 2019, Volume: 3, Issue: 1 Research Contents Molecular Docking and Molecular Dynamics of L-Glycyl-L-Glutamic Acid Dipeptide Bilge Bıcak, Serda Kecel Gunduz, Yagmur Kokcu, Aysen E Ozel , Sevim Akyuz Assessment of heavy metal pollution in the Tasik-Turkey Lake District Kadir Oruçoğlu, Mehmet Beyhan Assessment of slide types of susceptibility to landslides in the Ermanek River catchment area (Kerman) using artificial neural network methods Senem Tekin, Tolga Çan Deter Volatile Components of Flowers and some features morphology of summer lime (Tilia platyphyllos Scop.) Sedef Koç, Hüseyin Fakir Investment risk assessment of Siirt Madenköy copper mine in Turkey Merve Karaabat Varol, İbrahim Uğur, Selamet G. Erçelebi Leadership in Maritime Leadership Motivation and fear Leyla Tavacıoğlu, Umut Taç, Özge Eski , Neslihan Gökmen, Burak Uzun, Ufukcan Tirgil D Object detection using new descriptors with RGB-D Erkut Arıcan, Reka Be for Bluetooth Tarkan Aydın and Vacuum-Based Smart Applications Aydın Güllü, Musa Çağlar file De Windows operating conditions with deep learning Mahmut Tokmak, Ecir Uğur Küçüksille, Halilat Wild Tourism District, Antal. , Yassin Onel, Serkan Ozdemir, Ahmet Koka

Aöf Sınav Giriş Belgesi 2019 Bahar

6 Bilge International Journal of Science and Technology Research Year: 2019, Volume: 3, Issue: 1 Research Contents Molecular Docking and Molecular Dynamics of L-Glycyl-L-Glutamic Acid Dipeptide Bilge Bıcak, Serda Kecel Gunduz, Yagmur Kokcu, Aysen E Ozel , Sevim Akyuz Assessment of heavy metal pollution in lakes of Kadir Lake District Oruçoğlu, Mehmet Beyhan Assessment of landslide vulnerability of Ermenek Basin (Karaman) with artificial neural network method Senem Tekin, Tolga Çan Some morphological characteristics of summer scope.) Sedef Koç,ç Hüseyin Fakir Assessment Siirt Madenköy copper mine investment risk in Turkey Merve Karaabat Varol, İbrahim Uğur, Selamet G. Erçelebi Leadership in my time: evaluating the impact of leadership motivation and fear Leyla Tavacıoğlu, Umut Tavacıoğlu, Öut Tavacıoğlu, GÖut Tavacıoğlu, Öut Tavacıoğlu Neslihan Gökmen, Burak Uzun, Ufukcan Tirgil D Object detection using a new outliner with RGB-D Erkut A rıcan, Tarkan Aydın Smart vacuum design based on Blu etooth Aydın Güllü, Musa Çağlar Deep learning detection of malicious windows executables Mahmut Tokmak, Ecir Uğlur Kü Wild Goat Hunting Tourism Map: Antalya Province Halil Suel District, Antalya Province, Halil Suel District, Yal Amir, Antalya Province.

7 Bilge International Journal of Science and Technology Research Web : Received: ISSN: X Received: e-issn: DOI: /bilgesci (1), 1-9, 2019 Molecular Docking and Molecular Dynamics Studies of L-Glycyl-L-Glutamic Acid Dipeptide Bilge Bıcak 1, 2, Serda Kecel Gunduz *1, Yagmur Kokcu 2, Aysen E. Ozel 1, Sevim Akyuz 3 Abstract: Dipeptide Gly-Glu (GE), which acts as a neurotransmitter, is made of glycine and glutamic amino. Acid used to treat diseases such as schizophrenia, Parkinson’s and Alzheimer’s. Gly-Glu dipeptide is an important peptide structure that helps prevent neurodegeneration, especially in Alzheimer’s disease. Caspases, which are cysteine ​​proteases, play an important role in the apoptotic death of neurons in Alzheimer’s disease. In patients with Alzheimer’s disease, there is an increase in caspase-3 immunoreactivity in the death of pyramidal neurons, where the main site of neuronal loss is indicated (Gervais et al. 1999). The molecular structure of GE dipeptide with anti-apoptotic properties is very important to explain the activation mechanism with caspase-3 protein. Molecular dynamics and molecular docking calculations were used to elucidate the most stable molecular conformation and capture the mechanism of GE activity with caspase-3. First, the GROMACS program was used to reveal the conformational variation of GE in the body. The stability of the peptide is ensured by confinement in 704 water molecules. Second, the Glide SP (standard precision) module of Maestro version 11.4 in the Schrödinger program was used to determine the binding and activity of the peptide with caspase-3 protein. In this study, the structure of this dipeptide, its pharmacological properties and its mechanism of action with the caspase-3 protein were investigated for the first time by molecular dynamics and docking calculations. Keywords: Gly-Glu, dipeptide, Molecular Dynamics, Molecular Docking, ADME 1. Introduction Alzheimer’s disease (AD) is one of the neurodegenerative diseases associated with dementia as a clinical symptom. This disease is caused by the accumulation of amyloid β-peptide (Aβ) consisting of 39 to 43 amino acids in the brain. Aβ causes neurodegeneration but its neurotoxic effects remain unclear. That Aβ induces apoptosis in the brain has been shown by various observations in vivo and in vitro. In recent years, studies based on the determination of compounds that can protect neurons are very important to reverse the degenerative effects caused by Aβ. For this reason, proteins and peptides are different

Aöf Sınav Giriş Belgesi 2019 Bahar

Sound Art, Ecology And Auditory Culture. Lisboa Soa 2016 2020

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